Platelet rich fibrin (PRF) is an autogenous biomaterial consisting of growth factors and cytokines entrapped in a fibrin matrix. It combines the fibrant sealant properties along with growth factors thereby providing an ideal environment for wound healing and regeneration of tissues. PRF is a second-generation platelet concentrate which is prepared from the patient’s own blood free of any anticoagulant. Present review of literature aims to provide details of PRF preparation and its application in dentistry