Background: Space closure is one of the most challenging processes in Orthodontics. Hence; the present study was undertaken for assessing the efficacy of anterior retraction in 18 versus 22 slot. Materials and methods: A total of 120 samples were included and broadly divided into 6 study groups as follows: Group A: 0.022” slot bracket and eastomeric chain for retraction, Group B: 0.022” slot bracket and nickel titanium coil spring for retraction, Group C: 0.018” slot bracket and eastomeric chain for retraction and Group D: 0.018” slot bracket and nickel titanium coil spring for retraction. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Significant results were obtained while comparing the tipping, rotation and rate of closure among all the study groups. Mean tipping was highest for group A and group B. Mean rotation was highest for group A and group B. Mean rate of closure was highest for group A and group B. Conclusion: Bracket slot 0.022” groups demonstrated maximum tipping, rotation and space closure rate.