Background: The tobacco epidemic claims 4.9 million lives globally each year with an expected 10 million annual deaths by 2020. Around the globe, 1.3 billion people are tobacco smokers over one-half of whom will die prematurely from a tobacco-related illness.

Methods: From April 2022 to January 2023, we conducted a prospective cohort research project at the Institute of Dental Sciences, Bareilly's centre for smoking cessation. Results: From April 2022 to April 2023, 1042 current smokers were monitored at a smoking cessation centre. The study's inclusion criteria were met by 122 subjects, who also volunteered to take part. The rates of abstinence were 36.3% after one year and 61.5% after three months (p=001). Age, alcohol use, anxiety scale, and exhaled carbon monoxide values were all adjusted for, yet there were no discernible changes in the abstention rates between the two groups, NRT or VAR. In multivariate analysis, factors associated to a precipitate smoking relapse were presence of anterior previous attempts (HR: 0.10; 95% CI: 0.030-0.328), living with smokers at home (HR: 2.541; 95% CI: 1.019-6.336), having five following visits (HR: 0.091; 95% CI: 0.017-0.500) and having minimal withdrawal syndrome reveled on follow up (HR: 0.23; 95% CI: 0.08-0.662). Whereas, factors associated to quit delay was the use of NRT at the expense of VAR (HR: 4.966; 95% CI: 2.81-8.76).