Aim: To compare remineralizing potential of novel agent‑ Pine bark extract and herbal oil-arimedadi thailam with conventional remineralizing agent.

Material and Methods: An in vitro study was done to compare remineralizing potential of Pine bark extract and herbal oil-Arimedadi thailam with conventional remineralizing agent Caesin phosphopeptide-amorphous calcium phosphate (CPP-ACP). Forty human premolars were covered with nail varnish except for 4 mm × 4 mm exposed window on the facial aspect, which was treated with 37% phosphoric acid for 30 s. Samples were then randomly divided into four groups (n = 10): Group I –Pine Bark extract, Group II –Arimedadi thailam, Group III – Casein phosphopeptide‑amorphous calcium phosphate, and Group IV – Control. The samples in each group were treated with the remineralizing agent, after which they were rinsed with deionised water, dried, and stored in artificial saliva. The same procedure was repeated for the span of 14 days. Depth of demineralization and remineralization was analysed using Raman microscopy. Data were analysed using the Statistical Package SPSS 22.0 and level of significance was set at P < 0.05. ANOVA test was used to analyse the depth of demineralization and remineralization.

Results: The highest remineralization was observed in Group 2 (Herbal Oil), followed by Group 1 (Pine Bark Extract) and Group 3 (CPP-ACP Toothpaste), while the lowest remineralization potential was noted in Group 4 (Control).