Masticatory function is a crucial component of oral health, and oral rehabilitation should focus on preserving or restoring proper function. The effectiveness of prosthodontic treatment depends on how well patients can adapt to a changed oral environment that includes the prosthesis indicated. The aim of this review is to provide an insight into neuroplastic changes in the brain due to various modalities of prosthetic treatment and facilitate a better understanding of neurological pathways involved when changes in stimulus are presented to the stomatognathic system.